In recent years, the overall incidence of colorectal cancer has declined in many countries, but the incidence of young people is increasing. According to research estimates, by 2030, 1 in 10 people under the age of 50 will develop colorectal cancer and 1 in 4 people will develop rectal cancer. Compared with the past, most colorectal cancer patients are older than 50 years old, and young-onset colorectal cancer patients younger than 50 years old are more likely to be delayed due to the delay of examination, and most of the patients are at an advanced stage at the time of diagnosis. And the tumor is aggressive. Many young colorectal cancer patients have no family history or related genetic factors. Relevant studies have also pointed out that some lifestyles, such as sedentary, obesity, and eating habits, are risk factors for young colorectal cancer.
Vitamin D (vitamin D) is a known protective factor for colorectal cancer. In addition to exposure to light, dietary intake of foods rich in vitamin D, such as fish, mushrooms, eggs, milk, etc., is also a way to increase the content of vitamin D in the body. However, insufficient intake of vitamin D in the modern diet has increased since the 1980s. A team of number list researchers at Dana-Farber Cancer Institute, in collaboration with the Department of Epidemiology at Harvard School of Public Health, noticed this and started a prospective cohort study in 1989. ), to further clarify whether insufficient vitamin D intake is associated with the increasing incidence of young colorectal cancer. The results suggest that increasing dietary intake of vitamin D may help prevent the development of young-onset colorectal cancer or precancerous colon polyps (possibly a precursor to colorectal cancer). 2021) published in the journal Gastroenterology in July . Participants in the study, which included more than 94,000 female caregivers between the ages of 25 and 42, calculated their total vitamin D intake.
Including diet and supplements, and biennially surveyed the women. Statistics, diet, lifestyle factors, questionnaires with medical and other health-related information. The primary endpoint of the study was whether colorectal cancer was diagnosed before age 50. Questionnaires also asked whether they had undergone colonoscopy or sigmoidoscopy, and whether colorectal polyps were found. The results of the study indicated that from 1991 to 2015, there were 111 cases of young colorectal cancer and 3317 cases of rectal polyps. The hazard ratio analysis found that people with higher total vitamin D intake had a significantly lower risk of developing young-onset colorectal cancer. In addition, the odds ratio (odd ratio) also showed that total vitamin D intake was the same as the development of colorectal polyps before the age of 50 years. "Our results further support that vitamin D may be important for the prevention of colorectal cancer in young adults," said the research team. "In this way, we can make appropriate dietary and lifestyle recommendations and determine the risk of young-onset colorectal cancer.